The Human Micro Biome

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This study is important because the finding highlight the importance of performing longitudinal microbiome studies to examine the influence of microbial communities on health and disease. With recent health concerns regarding the development of antibiotic resistance, understanding how current treatment affect bacteria and subsequent diseases activity will allow us to identify and develop directed therapies for AD that modify the skin microbiome, potentially reducing the use of systemic antibiotic.

The article, “ Temporal shift in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis by Kong et al. address how there is a shift in bacterial diversity during flares and post-treatment. It was clear from the abstract of the article that this is no sample issue. In fact the article was fairly confusing for the first few paragraphs. The authors start by giving definitions in the abstracts and just jumped to the results, without an introduction paragraph. Everything was introduced in the abstract, but I would rather have an introduction paragraph to work off of. Overall this article isn’t straightforward in the beginning and it’s not until the second page that you realize where the article is headed. In order to have more people engaged and read the whole article it needs a more concise introduction. The piece, when taken as a whole, is relevant to the topic and gave us some insight into the shift that occurs during AD flare.

Work cited

1. Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis

Heidi H. Kong, Julia Oh, Clay Deming, Sean Conlan, Elizabeth A. Grice, Melony A. Beatson, Effie Nomicos, Eric C. Polley, Hirsh D. Komarow, NISC Comparative Sequence Program, Patrick R. Murray, Maria L. Turner, and Julia A. Segre

Genome Res. May 2012 22: 850-859; Published in Advance February 6, 2012, doi:10.1101/gr.131029.111

2. Salava, Alexander, and Antti Lauerrma. "Role of the Skin Microbiome in Atopic Dermatitis." Clinical and Translational Allergy. N.p., 2014. Web. 02 June 2015.

3. Mary. "Eczema (Atopic Dermatitis): Genetic And Environmental Skin Condition - Essays." Eczema (Atopic Dermatitis): Genetic And Environmental Skin Condition - Essays. N.p., 20 Apr. 2012. Web. 02 June 2015.

4. Bruce Agnew. "2014 News Feature: The Skin Microbiome: More than Skin Deep." 2014 News Feature: The Skin Microbiome: More than Skin Deep. National Human Genome Research Institute, 20 Nov. 2014. Web. 02 June 2015.

5. Genetically Programmed Differences in Epidermal Host Defense between Psoriasis and Atopic Dermatitis Patients

Patrick L. J. M. Zeeuwen, Gys J. de Jongh, Diana Rodijk-Olthuis, Marijke Kamsteeg, Renate M. Verhoosel, Michelle M. van Rossum, Pieter S. Hiemstra, Joost Schalkwijk PLoS One. 2008; 3(6): e2301. Published online 2008 June 4. doi: 10.1371/journal.pone.0002301