Synthesis of Cyclohexanecarboxylic Acid

Expérience 3C

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Praktikum Anorganic and Organic Chemestry I

Gringnard Reaction

Column Chromatography

Synthesis of Cyclohexanecarboxylic acid

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1. Abstract

Cyclohexanecarboxylic acid has been synthetized through Grignard reaction of Magnesium, Bromocyclohexane and Carbon Dioxide. The yield of the reaction was about 38%.

1. Introduction

Cyclohexanecarboxylic acid is used in preparing flavoring agents, internal plasticizers, pesticides, dyes, textile treatment agents, fungicides, and pharmaceuticals. Carboxylic acid provides covalently linked structure with hydroxy group. It can form amide derivatives. It is a metal chelator. Chelation is applied in metal complex chemistry, organic and inorganic chemistry, biochemistry, and environment protection. It is used in chemotherapeutic treatments for metal poisoning. [2]

1. Substances characteristics

Cyclohexanecarboxylic acid has been synthetized through rignard reaction of Magnesium, Bromocyclohexane and Carbon Dioxide.

General characteristics [1]

Substance

MW

[g/mol]

Density

[g/ml]

Melting point

[°C]

Boiling point [°C]

Bromocyclohexane

163.06

1.324

166-167

Magnesium

24.31

1.74

648

1090

Carbon Dioxide

44.01

−78.5

-57

Cyclohexanecarboxylic acid

128.17

1.033

29-31

232-233

Reaction quantities [1]

Substance

MW [g/mol]

Eq

Moles

[mmol]

Mass

[g]

Volume

[ml]

Purity

[%]

Bromocyclohexane

163.06

1.00

50

8.15

6.3

98

Magnesium

24.31

1.64

82.27

2

99.98

Carbon Dioxide

44.01

10

500

22

99.8

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Potential hazards [1]

Substance

GHS Pictograms