Biochemistry of Alcohol Metabolism

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Right now the nicotine is likewise empowering the nervous system, creating the release of adrenaline into the body. Adrenaline produces expanded heart rate and breath multiplying those emotions of strain and being wired. At this point, the smoker is edgy for another cigarette, which, he demands, will be relaxing!

EFFECT OF NICOTINE WITH ETHANOL

There was a study to assess the hepatotoxicity of incessant nicotine introduction and to contrast the impact of nicotine alone with its mix with ethanol. The discovery gave confirmation of hepatic harm brought on by perpetual nicotine presentation and demonstrated that ethanol supplementation expand the wounds of rodent liver. Indeed, the information demonstrated that long term nicotine treatment advanced oxidative anxiety, expanded lipid peroxidation, adjusted movement of cancer prevention agent compounds, changed the histological parameters in liver tissue and disturbed biochemical parameters in serum. The ethanol supplementation amid interminable nicotine organization applied added substance adverse impacts on the biochemical parameters of liver capacity, cancer prevention agent protection framework and lipid peroxidation, and irritated the histopathological changes in liver tissue by over-creation of damaging free radical because of both digestion systems of nicotine and ethanol more noteworthy than created amid digestion system of nicotine alone [7].

REFERNCES

[1] Bosron, W.F.; Ehrig, T.; & Li,T.-K. Genetic factors in alcohol metabolism and alcoholism. Seminars in Liver Disease 13(2):126-135, 1993.

[2] Wallgren, H. Absorption, diffusion, distribution and elimination of ethanol: Effect on biological membranes. In: International Encyclopedia of Pharmacology and Therapeutics. Vol. 1. Oxford: Pergamon, 1970. pp. 161-188.

[3] Ronald R Watson, Handbook 0/ Nutrition in the Aged, CRC Press, 2nd edition, Vol. 11, pp. 317·329,1994.

[4] “Alcohol: Balancing Risks and Benefits.” Harvard School of Public Health (2010). n. pag. Web. 22 May 2010.

[5] C. B. Sherman, “Health effects of cigarette smoking,” Clinics in Chest Medicine, vol. 12, no. 4, pp. 643–658, 1991.

[6] “The Biochemistry and Physiology of Smoking” published in the Texas Department of Health Bulletin, 2005 Carol Pierce-Davis, Ph.D. Psychologist, Founder and Director of LifeEd/TeenEd.

[7] IOSR Journal Of Environmental Science, Toxicology And Food Technology (IOSR-JESTFT) e-ISSN: 2319-2402,p- ISSN: 2319-2399.Volume 8, Issue 1 Ver. V (Feb. 2014), PP 72-82 www.iosrjournals.org

METHOD

In this experiment, readings will be taken twice after every 15mins because nicotine and ethanol needs minimum of ten to fifteen minutes to diffuse through cell membranes to enter blood. First reading will be immediately after the subject finishes the drink/smoke and then after fifteen minutes. According to the prior studies, blood alcohol levels are elevated after few minutes of consumption of ethanol. Diffusion is a slow process, hence the effect of ethanol and nicotine on the body will be determined after fifteen minutes of their consumption.